>>292507361
I haven't used a Quest so can't comment on comfort, but you'll want to get prescription lenses if you can. It's well worth it to avoid scratching up your lenses, which hapenned to me while I waited for my lenses to arrive.
Only vision related reason the Quest might be better for you is if your IPD is too big or too small for the Rift S. Mine is slightly above average and I find it's hard to get the sweet spot right on Rift S.