>>321201635
>comfort
I spent about 12 hours in my Index last night with no issues with comfort, so I wouldn't worry about that. If you find it too front heavy add a counterweight to the back.
>wires
Wires are annoying but you get used to it. Try not to step on them too much, but you will almost certainly have to RMA a wire if you play regularly. 
>space
Having a bigger space is nice but you can make do with even less than a square meter. The main benefit is for when you're moving around a lot (beat saber, vrc) or you're moving quickly (vrfps), but again you can make do. There's also a "seated" mode which assumes you don't move but it's kinda shitty, even a small room scale setup is better in my opinion.
>spoiler
kinda shitty but I can't think of any better vr h-games [spoiler]that aren't vrc[/spoiler]