>>315798231
yes, please UV unwrap first by marking seams, newer versions of substance can unwrap for you but it tries to keep everything on one island and causes extreme texture warping.
after you get everything set up, add layers for each of the colours, mask them out so it looks close to what you'd like, and then use a baked lighting material or a fill layer with a baked lighting filter on top to add ao/lighting detail to your texture so it'll look good in vrchat.
https://www.youtube.com/watch?v=LGHZq11RIkU