>>271918629
With M4? No. It's only harder on bolt action sniper rifles and the revolver.
You either do the meme over the bolt pinching thing and probably slam yourself in the headset in the process or you use your other hand and slam controllers together.
I found M99, due to its size and the fact it's a bullpup actually okay to operate, and you can shoot it with one hand before you're done reloading.
Other than the fire selector, I'd also say being a southpaw makes reloading the real M4 easier too.