Trannie
Short version of the word Transgender, Transvestite and Transsexual. Often mistaken as a slur against mentally ill people. Used mainly online to not keep typing unnecessarily long words over and over again.
Guy 1: "I heard you're a trannie" 
Trannie: "Racist bigot! Go die fascist pig!" 
Guy 2, a cuck: "Dude that's not gender-friendly of you! Take that shit back!